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Courses in MED Biological Chemistry
Biochemists are investigators who apply the scientific method to determining the molecular bases of biological processes. Accordingly, students in the Department of Biological Chemistry receive training in identifying important biological problems, in developing models of the underlying biochemistry of these processes, and in using appropriate bio-chemical tools (e.g., protein, nucleic acid, lipid and carbohydrate chemistry) for testing the models.
Biological Chemistry (BIOLCHEM)

All courses in Biological Chemistry (BIOLCHEM) are listed in the Online Schedule of Classes under the Medical School. Courses not listed in the LSA Course Catalogue and not cross-listed through an LSA department count as non-LSA course work (see “Non-LSA Course Work” on the LSA website).

The following count as LSA courses for LSA degree credit.

BIOLCHEM 398. Undergraduate Research in Biochemistry
Consent of instructor required. Junior standing and permission of the Biological Chemistry Professor who will supervise the research. (1 - 4). (BS). (INDEPENDENT). May be repeated for a maximum of 4 credits.

Independent undergraduate research in biochemistry.

BIOLCHEM 415. Introductory Biochemistry
Two terms of organic chemistry. (3). (BS). May not be repeated for credit. No credit granted to those who have completed or are enrolled in BIOLOGY 310 or 311, MCDB 310 or 311, CHEM 451, or BIOLCHEM 451 or 515. F.

A one-term introductory biochemistry course that covers the biochemistry of the living state, the chemistry of amino acids, proteins, nucleic acids, carbohudrates, lipids, and steroids, energy transformations and chemical reactions in living cells, function of immune system and action of hormones, and self-regulation and self-replication of living organisms.

BIOLCHEM 416. Introductory Biochemistry Laboratory
Qualitative analysis; prior or concurrent election of BIOLCHEM 415 or 451/452 or CHEM 451/452. (3). (BS). May not be repeated for credit. No credit granted to those who have completed or are enrolled in BIOLOGY 429 or BIOLCHEM 516. F.

BIOLCHEM 451 / CHEM 451. Advanced Biochemistry: Macromolecular Structure and Function
CHEM 215, 260, 351 and BIOLOGY 171 or 172. (4). (BS). May not be repeated for credit. F.

Taught from a chemical perspective with emphasis on understanding biochemical phenomena through chemical structure and mechanism, this course is intended for students pursuing the BS concentration in biochemistry. It provides an in-depth treatment of such topics as protein/nucleic acid structure, protein folding/stability, enzyme mechanisms/kinetics, bioenergetics/ photosynthesis, and the regulation of metabolic pathways.

BIOLCHEM 452 / CHEM 452. Advanced Biochemistry: Cellular Processes
CHEM 351 or MCDB 310 or BIOLCHEM 415, (completed with a minimum grade of C- or better). Consent of instructor required. (Prerequisites enforced at registration.) (4). (BS). May not be repeated for credit. W.

This course focuses on the biochemistry of fundamental cellular processes. Topics include mechanisms for the integration of metabolism in both bacterial cells and in multicellular organisms, the process of gene expression focusing on the biochemistry of gene transcription, and mRNA translation. It generally emphasizes chemistry and enzymology of metabolic transformations, enzyme reaction mechanisms, and protein and nucleic acid structure and function.

BIOLCHEM 499. Biochemical Research for Undergraduates: Laboratory
Consent of instructor required. BIOLCHEM 415 or 451/452; permission of the course director. (1 - 6; 1 - 4 in the half-term). (BS). (INDEPENDENT). May be repeated for credit. F, W, Sp/Su.

BIOLCHEM 576 / PHRMACOL 576 / PHYSIOL 576. Signal Transduction
Two terms of organic chemistry; BIOLCHEM 415 or 451/452. Physical Chemistry is strongly recommended. (1). (BS). May not be repeated for credit. F.

A review of hormones and neurotransmitter receptors as well as the cellular effectors that are regulated by receptor activation. Oncogene products as signal transducers and the interaction of the known signaling pathways are also covered. The various techniques used to study signal transduction as well as important experimental strategies employing these techniques will also be presented.

BIOLCHEM 673 / CHEM 673. Kinetics and Mechanism
BIOLCHEM 550, CHEMBIO 501, or equivalent, undergrad calculus. Physical Chemistry is recommended. (2). (BS). May not be repeated for credit.

This course will cover the investigation of enzyme mechanisms with an emphasis on ligand binding to macromolecules, transient kinetics, steady-state kinetics, and inhibition. The kinetic and thermodynamic concepts that govern the action of enzymes will be explored.

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