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Note: For descriptions of classes each term, see the LSA Course Guide
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Courses in LSA Biophysics
The goal of the biophysical sciences is to develop a quantitative understanding of the living world. They rely on the principles of physics, chemistry and biology, and find applications in medicine and engineering. The biophysical sciences range in scope from modeling biomolecular function to understanding cellular mechanics or brain function through the rigorous use of physical methods and concepts.
Biophysics (BIOPHYS)
BIOPHYS 115. (In)organic Nutrition
Enrollment restricted to first-year students, including those with sophomore standing. (3). (NS). (BS). May not be repeated for credit.

Life, at least as we know it, would be impossible without 20 "trace elements". These are "inorganic" as opposed to "organic", or carbon based, chemicals. We will explore what roles these elements play, and what happens if they aren't present. We will also look at elements, not normally found in biology, that can be important both in causing disease (i.e., environmental toxins) and in curing disease (e.g., anti-cancer drugs).

BIOPHYS 116. Introduction to Medical Imaging
Enrollment restricted to first-year students, including those with sophomore standing. (3). (NS). (BS). May not be repeated for credit.

This first year seminar surveys the methods of modern medical imaging for clinical and scientific purposes, highlighting basic concepts in chemistry, physics, and biochemistry and the biophysical foundations upon which all current tools for biomedical imaging rest. We explore the historical development of the underlying science of radiography, computed tomography (x-rays of a selected plane of the body), diagnostic ultrasound, nuclear medicine, and magnetic resonance imaging. This seminar also touches on the societal implications of imaging such as radiation risks, health care costs, and future directions in medical research.

BIOPHYS 120. The Discovery of the DNA Double Helix and its Hidden Mysteries
(3). (NS). (BS). (QR/1). May not be repeated for credit.

Intended for students interested in the natural sciences and medicine, this course uses modern techniques to explore the scientific journey leading to the discovery of the structure of DNA. It presents demonstrations of state-of-the-art biophysical laboratory techniques now widely used in biophysical studies of DNA and other biomolecules, including NMR, single molecule techniques, and X-ray crystallography.

BIOPHYS 280. Biophysics Undergraduate Research (UROP)
(1 - 4). (EXPERIENTIAL). May be repeated for a maximum of 8 credits. Credit is granted for a combined total of 8 credits in any UROP research courses.

This course gives students in UROP (Undergraduate Research Opportunity Program) the opportunity to engage in independent research in a research laboratory under the supervision of a Biophysics faculty member.

BIOPHYS 290 / PHYSICS 290. Physics of the Body and Mind
PHYSICS 125 or 135 or 140 or 160. (Prerequisites enforced at registration.) MATH 115 or equivalent AP credits. (3). (NS). (BS). (QR/2). May not be repeated for credit.

The course discusses and explores basic physical concepts, and apply them to the human body, organs, and cells. Its aim is to provide understanding of biological function in terms of fundamental physics principles. It is intended for students interested in the application of physics to biology, biochemistry, physiology, psychology, genetics, medicine, bioengineering and related life sciences.

BIOPHYS 370 / CHEM 370 / PHYSICS 370. Physical and Chemical Principles Behind Biology and Medicine
MATH 215; and PHYSICS 235 or 240. (Prerequisites enforced at registration.) CHEM 130 or placement in 210. (3). (NS). (BS). May not be repeated for credit. F, W.

This course is an introduction to the fundamental physical and chemical principles of biophysics. It covers quantum aspects of matter, thermodynamics, kinetics and statistical mechanics in the context of biological applications.

BIOPHYS 399. Research in Biophysics
(1 - 4). (BS). (INDEPENDENT). May be repeated for a maximum of 8 credits.

This course gives biophysics concentrators the opportunity to engage in independent research in a research laboratory under the supervision of a faculty member.

BIOPHYS 415. Directed Study
(1 - 4). (BS). (INDEPENDENT). May be elected twice for credit. May be elected more than once in the same term.

A program of supervised study agreed upon by a student and a member of the faculty.

BIOPHYS 417 / CHEM 417 / PHYSICS 417. Dynamical Processes in Biophysics
MATH 216 or 256 or 286 or 296 or 316; and PHYSICS 340 or BIOPHYS 370 or CHEM 463. (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit.

The physical basis of diffusive processes in biology and biochemistry, and optical spectroscopic means for measuring its rates. Topics include: membrane electrical potentials, nerve impulses, synaptic transmission, the physics of chemoreception by cells, motion and reaction kinetics of membrane components, optical microscopy, visible and UV light absorption, fluorescence and phosphorescence, quasielastic light scattering, mathematics of random fluctuations, and chaotic processes in biology.

BIOPHYS 433 / PHYSICS 433. Biocomplexity
CHEM 417 or PHYSICS 417, or PHYSICS 406; or graduate standing. (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit. Rackham credit requires additional work.

This course on biocomplexity explores concepts of nonlinear dynamics and the interplay between chaos and order in biological systems.

BIOPHYS 435. Biophysical Modeling
BIOPHYS/PHYSICS 417 or Graduate Standing. (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit. Rackham credit requires additional work.

This course explores biophysical modeling and the associated computational tools on length scales ranging from atomistic simulations to multicellular networks.

BIOPHYS 440 / CHEM 440. Biophysics of Diseases
BIOPHYS 370 or CHEM 370 or PHYSICS 370. (3). (BS). May not be repeated for credit.

This course deconstructs current and emerging diseases in terms of the malfunctioning of nucleic acids, proteins, and membranes and the interactions between them. The diseases covered includes Alzheimer's, Parkinson's, Creutzfeldt-Jakob disease (or Mad-Cow disease), HIV, a variety of bacterial infections, and other biological disorders.

BIOPHYS 450 / PHYSICS 450. Laboratory Techniques in Biophysics
BIOPHYS 370 or CHEM 370 or PHYSICS 370; or PHYSICS 390; or CHEM 452 or BIOLCHEM 452; or graduate standing. (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit. Rackham credit requires additional work.

This laboratory course teaches essential laboratory skills in biophysics through hands-on experiments, computational work, and a supporting lecture.

BIOPHYS 454 / CHEM 454. Biophysical Chemistry II: Macromolecular Structure and Dynamics
CHEM 453 or 463, and CHEM 451/452 or equivalent. (3). (BS). May not be repeated for credit. W.

This course builds on the CHEM 451-453 sequence and aims at providing an understanding of the structure and dynamics of biological macromolecules. After introducing the necessary nomenclature and reviewing thermodynamic principles, modern techniques to characterize the structure and dynamics of biopolymers will be the focus. Sedimentation, electrophoresis, mass spectrometry, X-ray diffraction, scattering, and spectroscopic techniques such as absorption, circular dichroism, fluorescence and NMR will be covered. Both physical principles and practical applications in the Life Sciences will be highlighted.

BIOPHYS 463 / BIOINF 463 / MATH 463. Mathematical Modeling in Biology
MATH 214, 217, 417, or 419; and MATH 216, 256, 286, or 316. (3). (BS). May not be repeated for credit.

An introduction to the use of continuous and discrete differential equations in the biological sciences. Modeling in biology, physiology and medicine.

BIOPHYS 495. Senior Seminar in Biophysics
BIOPHYS 450 or PHYSICS 450; or graduate standing. (Prerequisites enforced at registration.) (2). (BS). May not be repeated for credit. Rackham credit requires additional work.

This course speaks to the exchange of scientific information through professional publications and meetings. Students focus on how to write scientific papers and present at conferences and develop these skills through practical exercises.

BIOPHYS 498. Senior Thesis
BIOPHYS 399. (1 - 4). (BS). (INDEPENDENT). May not be repeated for credit.

This course gives biophysics concentrators the opportunity to cap their educational experience with a senior thesis based on their research.

BIOPHYS 499. Honors Thesis
BIOPHYS 399. (1 - 4). (BS). (INDEPENDENT). May not be repeated for credit.

This course gives biophysics concentrators the opportunity to cap their educational experience with an honors thesis based on their research.

BIOPHYS 520 / CHEM 520. Biophysical Chemistry I
CHEM 463, BIOLCHEM 415, or CHEM 420; permission of course director. (3). (BS). May not be repeated for credit. F.

This course is the first of a two term biophysical chemistry series BIOPHYS 520/521. The course offers an overview of protein, nucleic acid, lipid and carbohydrate structures.

BIOPHYS 521 / CHEM 521. Biophysical Chemistry II
CHEM 461, BIOLCHEM 415, and CHEM 430; and permission of course director. (3). (BS). May not be repeated for credit. W.

This course gives background applications of several physical techniques used in Biophysical research. General principles of spectroscopy will be explained. Macromolecular structure determination by X-ray diffraction and two-dimensional NMR will be treated in detail. IR, Raman, CD, EXAFS, EPR and ESEEM will be introduced.

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