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Courses in MED Biological Chemistry

All courses in Biological Chemistry (BIOLCHEM) are listed in the Online Schedule of Classes under the Medical School. Courses not listed in the LSA Course Catalogue and not cross-listed through an LSA department count as non-LSA course work (see “Non-LSA Course Work” on the LSA website).

The following count as LSA courses for LSA degree credit.

Biological Chemistry (BIOLCHEM)
BIOLCHEM 416. Introductory Biochemistry Laboratory
Qualitative analysis; prior or concurrent election of BIOLCHEM 415 or 451/452 or CHEM 451/452. (3). (BS). May not be repeated for credit. No credit granted to those who have completed or are enrolled in BIOLOGY 429 or BIOLCHEM 516. F.

BIOLCHEM 501 / BIOPHYS 501 / CHEM 501 / CHEMBIO 501 / MEDCHEM 501 / PHRMACOL 501. Chemical Biology I
(3). (BS). May not be repeated for credit.

This course will provide a high-level overview on the structure, function and chemistry of biological macromolecules including proteins, nucleic acids and carbohydrates. Topics include protein and nucleic acid folding, energetic of macromolecular interactions (kinetics and thermodynamics), and mechanistic enzymology. Using specific examples from the current literature, each topic will stress how chemists have used molecular level tools and probes to help understand the specific systems under study. The over arching theme in this course will be the structure and function and intimately linked.

BIOLCHEM 502 / BIOPHYS 502 / CHEM 502 / CHEMBIO 502 / MEDCHEM 502 / PHRMACOL 505. Chemical Biology II
CHEMBIO 501. (3). (BS). May not be repeated for credit.

This course is a continuation of Chemical Biology 501. The basic concepts obtained in Chemical Biology 501 will be applied to and demonstrated in three broad areas of interest to both chemists and biologists. The first topic will discuss combinatorial methods including SELEX and gene shuffling, combinatorial organic synthesis, high throughput screening and chemical genetics. The second topic will focus on signal transduction, emphasizing general concepts (at the molecular level) and how small molecules have been used to probe and modulate signal transduction pathways. The final topic will cover protein translation, stressing mechanistic aspects of protein synthesis and folding in vivo.

BIOLCHEM 504 / ANATOMY 504 / BIOMEDE 504 / MICRBIOL 504. Cellular Biotechnology
(3). (BS). May not be repeated for credit.

BIOLCHEM 505 / CHEM 505. Nucleic Acids Biochemistry
CHEM 451 and 452; or BIOLCHEM 451 and 452; or graduate standing. Consent of instructor required. (Prerequisites enforced at registration.) CHEM 451 and 452; or graduate standing. (3). (BS). May not be repeated for credit.

This course will provide a high-level overview on the structure, function and biology of nucleic acids. After gaining a high-level background in nucleic acid structure and their interactions with proteins, we will study important RNA-based biological processes, including pre-mRNA splicing, translation, RNAI and RNA decay.

BIOLCHEM 528 / CHEM 528 / MEDCHEM 528. Biology and Chemistry of Enzymes
BIOLCHEM 550, CHEMBIO 501 or equivalent, and one semester of Organic Chemistry. (2). (BS). May not be repeated for credit.

This course will cover the chemical and catalytic mechanisms of enzyme-catalyzed reactions, with an emphasis on organic and organometallic cofactors in biology and mechanisms of group transfer reactions, redox reactions, rearrangements, decarboxylations, carboxylations, and methylation.

BIOLCHEM 550. Macromolecular Structure and Function
Two terms Organic Chemistry, introductory Biochemistry/permission of instructor. (3). (BS). May not be repeated for credit.

This course will relate protein structure to various aspects of protein function. The course will begin with a general introduction to three-dimensional protein structure including discussion of structure determination methods and forces in protein structure and stability. Significant sections of the course include (i) binding and allosterism, (ii) enzyme catalysis, (iii) protein-nucleic acid interaction, and (iv) signal transduction and membrane proteins. The emphasis will be to relate details of structure to the function of the proteins discussed. The course will include a molecular graphics component aimed at hands-on experience for the students.

BIOLCHEM 551 / BIOINF 551 / BIOMEDE 551 / CHEM 551 / PATH 551. Proteome Informatics
The course is fundamentally interdisciplinary. Undergraduate biochemistry and calculus, or permission of instructor. (3). (BS). May not be repeated for credit.

Introduction to proteomics, mass spectrometry, peptide identification and protein inference, statistical methods and computational algorithms, post-translational modifications, genome annotation and alternative splicing, quantitative proteomics and differential protein expression analysis, protein-protein interaction networks and protein complexes, data mining and analysis of large-scale data sets, clinical applications, related technologies such a metabolomics and protein arrays, data integration and systems biology.

BIOLCHEM 591 / PHRMACOL 591 / PHYSIOL 591. Special Topics in Signal Transduction
Course in Biochemistry and signal transduction or Instructor permission. (2). (BS). May not be repeated for credit.

This course is literature based discussion course that will cover both seminal discoveries in signal transduction as well as recent advances in the field.

BIOLCHEM 602 / BIOPHYS 602 / CHEM 602 / PHRMACOL 602. Protein Crystallography: Principles of Macromolecular Crystallography
Physical Chemistry. Graduate standing. (3). (BS). May not be repeated for credit.

Fundamental of the methods for determining 3-dimensional structures of large molecules by x-ray crystallography. Aimed at students who expect to use crystallography as a major tool for their research, and at those who want in-depth knowledge of the methods in order to analyze structure data.

BIOLCHEM 631 / BIOLOGY 631 / HUMGEN 631 / MICRBIOL 631 / PHRMACOL 631. Genetic Program Student Seminar
Graduate standing and permission of instructor. (1). (BS). May not be repeated for credit.

BIOLCHEM 640. Regulatory RNA and Control of Gene Expression
(2). (BS). May not be repeated for credit.

A literature-based course covering post-transcriptional gene regulation, with emphasis on recent discoveries involving small RNAs and RNAi. We will cover mechanisms for endogenous post-transcriptional gene regulation and look at biological roles for such regulation. We will examine the use of RNAi as a tool to study gene function in animals.

BIOLCHEM 650. Mechanisms of Eukaryotic Gene Expression
Introductory Biochemistry or permission of instructor. (3). (BS). May not be repeated for credit.

Topics will cover eukaryotic RNA polymerases, general transcriptional factors, mechanisms of transcriptional regulation mediated by protein and RNA, and chromatin structure and modification/remodeling. An emphasis will be placed on structural and mechanistic aspects of transcriptional regulation. The course will consist a combination of lectures and participatory discussions of primary research literature.

BIOLCHEM 673 / CHEM 673. Kinetics and Mechanism
BIOLCHEM 550, CHEMBIO 501, or equivalent, undergrad calculus. Physical Chemistry is recommended. (2). (BS). May not be repeated for credit.

This course will cover the investigation of enzyme mechanisms with an emphasis on ligand binding to macromolecules, transient kinetics, steady-state kinetics, and inhibition. The kinetic and thermodynamic concepts that govern the action of enzymes will be explored.

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