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Courses in LSA Chemistry
Chemistry (CHEM)
CHEM 415. Responsible Conduct in Chemical Research
(1). May be elected twice for credit. May be elected more than once in the same term.

Every discipline at the University of Michigan engages in research. The approach to performing research varies significantly between disciplines. Half of the course will be discipline-specific research methods and half will be the responsible conduct of research (RCR). This course will teach research methods for the natural sciences. Topic areas include: appropriate citation of sources and avoiding plagiarism; authorship and publication practices and responsibilities; acquisition, management, ownership and sharing of data; research misconduct, including data fabrication and falsification; personal, professional and financial conflicts of interest; supervisory and mentoring relationships and responsibilities; responsibilities of collaborative research; protection of human beings and welfare of laboratory animals when research involves human participants and animal subjects. This will include an overview of example research projects, the methods for performing research, and the tools needed. The mechanisms for communicating research, such as conferences, articles, papers and books will be discussed. In addition there are areas common to conducting research in any discipline, such as appropriate citation of sources, authorship practices, acquisition, management and sharing of data.

CHEM 417 / BIOPHYS 417 / PHYSICS 417. Dynamical Processes in Biophysics
MATH 216 or 256 or 286 or 296 or 316; and PHYSICS 340 or BIOPHYS 370 or CHEM 463. (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit.

The physical basis of diffusive processes in biology and biochemistry, and optical spectroscopic means for measuring its rates. Topics include: membrane electrical potentials, nerve impulses, synaptic transmission, the physics of chemoreception by cells, motion and reaction kinetics of membrane components, optical microscopy, visible and UV light absorption, fluorescence and phosphorescence, quasielastic light scattering, mathematics of random fluctuations, and chaotic processes in biology.

CHEM 419. Intermediate Physical Organic Chemistry
CHEM 210 and CHEM 215. (3). (BS). May not be repeated for credit.

The mechanistic underpinnings of key reactions in organic synthesis are discussed in the context of the primary literature.

CHEM 420. Intermediate Organic Chemistry
CHEM 215 and 216 or their equivalents. (3). (BS). May not be repeated for credit.

CHEM 440 / BIOPHYS 440. Biophysics of Diseases
BIOPHYS 370 or CHEM 370 or PHYSICS 370. (3). (BS). May not be repeated for credit.

This course deconstructs current and emerging diseases in terms of the malfunctioning of nucleic acids, proteins, and membranes and the interactions between them. The diseases covered includes Alzheimer's, Parkinson's, Creutzfeldt-Jakob disease (or Mad-Cow disease), HIV, a variety of bacterial infections, and other biological disorders.

CHEM 447. Physical Methods of Analysis
CHEM 260 or 370 and 241/242. (3). (BS). May not be repeated for credit. F, W.

The course introduces the student to the principles and techniques of modern analytical chemistry. Atomic and molecular spectroscopy, mass spectrometry, and chromatographic separation techniques are stressed. Some discussion of contemporary electrochemistry is included. The principles of data collection and the processing and representation of analytical signals are introduced.

CHEM 461. Physical Chemistry I
CHEM 260 or 370 or BIOPHYS 370 or PHYSICS 370; and PHYSICS 240 or 235; and MATH 215 or CHEM 262. Should be elected concurrently with CHEM 462. (3). (BS). May not be repeated for credit. F.

This course provides an introduction to quantum mechanics and its application to chemistry. It is the second of a 3-term sequence in physical chemistry and builds on material introduced in CHEM 260. The Schrodinger Equation is solved in one, two, and three dimensions for important chemical problems. Group theory and quantum chemistry are used to understand chemical bonding and advanced spectroscopy.

CHEM 462. Computational Chemistry Laboratory
MATH 215, and prior or concurrent enrollment in CHEM 461. (1). (BS). May not be repeated for credit. F.

CHEM 463. Physical Chemistry II
CHEM 461/462. (3). (BS). May not be repeated for credit. No credit granted to those who have completed or are enrolled in CHEM 453. W.

This is the third of a three-term sequence in physical chemistry and focuses on thermodynamics and kinetics. Both classical thermodynamics (entropy, phase, and chemical equilibrium) and statistical thermodynamics are discussed. Fundamental theories underlying chemical kinetics are discussed and solid state structures are introduced.

CHEM 467 / AOSS 467 / EARTH 465 / ENSCEN 467 / ENVIRON 467. Biogeochemical Cycles
MATH 116, CHEM 210, and PHYSICS 240 (or 260). (3). (BS). May not be repeated for credit. F, W.

CHEM 501 / BIOLCHEM 501 / BIOPHYS 501 / CHEMBIO 501 / MEDCHEM 501 / PHRMACOL 501. Chemical Biology I
(3). (BS). May not be repeated for credit.

This course will provide a high-level overview on the structure, function and chemistry of biological macromolecules including proteins, nucleic acids and carbohydrates. Topics include protein and nucleic acid folding, energetic of macromolecular interactions (kinetics and thermodynamics), and mechanistic enzymology. Using specific examples from the current literature, each topic will stress how chemists have used molecular level tools and probes to help understand the specific systems under study. The over arching theme in this course will be the structure and function and intimately linked.

CHEM 502 / BIOLCHEM 502 / BIOPHYS 502 / CHEMBIO 502 / MEDCHEM 502 / PHRMACOL 505. Chemical Biology II
CHEMBIO 501. (3). (BS). May not be repeated for credit.

This course is a continuation of Chemical Biology 501. The basic concepts obtained in Chemical Biology 501 will be applied to and demonstrated in three broad areas of interest to both chemists and biologists. The first topic will discuss combinatorial methods including SELEX and gene shuffling, combinatorial organic synthesis, high throughput screening and chemical genetics. The second topic will focus on signal transduction, emphasizing general concepts (at the molecular level) and how small molecules have been used to probe and modulate signal transduction pathways. The final topic will cover protein translation, stressing mechanistic aspects of protein synthesis and folding in vivo.

CHEM 505 / BIOLCHEM 505. Nucleic Acids Biochemistry
Consent of instructor required. CHEM 451 and 452; or graduate standing. (3). (BS). May not be repeated for credit.

This course will provide a high-level overview on the structure, function and biology of nucleic acids. After gaining a high-level background in nucleic acid structure and their interactions with proteins, we will study important RNA-based biological processes, including pre-mRNA splicing, translation, RNAI and RNA decay.

CHEM 507. Inorganic Chemistry
CHEM 461. (3). (BS). May not be repeated for credit. F.

CHEM 511 / MATSCIE 510. Materials Chemistry
CHEM 461, BIOLCHEM 415, CHEM 430; and permission of course director. (3). (BS). May not be repeated for credit.

This course presents concepts in materials chemistry. The main topics covered include structure and characterization, macroscopic properties and synthesis and processing.

CHEM 515 / MACROMOL 518. Organometallic Chemistry
(3). (BS). May not be repeated for credit.

Systematic consideration of modern aspects of organometallic chemistry including main group and transition metal complexes. The structure and bonding in organometallic compounds are covered. Particular emphasis is placed on applications of homogeneous organometallic catalysis in polymer synthesis, industrial processes, and synthetic organic chemistry.

CHEM 520 / BIOPHYS 520. Biophysical Chemistry I
CHEM 463, BIOLCHEM 415, or CHEM 420; permission of course director. (3). (BS). May not be repeated for credit.

This course is the first of a two term biophysical chemistry series BIOPHYS 520/521. The course offers an overview of protein, nucleic acid, lipid and carbohydrate structures.

CHEM 521 / BIOPHYS 521. Biophysical Chemistry II
CHEM 461, BIOLCHEM 415, and CHEM 430; and permission of course director. (3). (BS). May not be repeated for credit.

This course gives background applications of several physical techniques used in Biophysical research. General principles of spectroscopy will be explained. Macromolecular structure determination by X-ray diffraction and two-dimensional NMR will be treated in detail. IR, Raman, CD, EXAFS, EPR and ESEEM will be introduced.

CHEM 528 / BIOLCHEM 528 / MEDCHEM 528. Biology and Chemistry of Enzymes
BIOLCHEM 550, CHEMBIO 501 or equivalent, and one semester of Organic Chemistry. (2). (BS). May not be repeated for credit.

This course will cover the chemical and catalytic mechanisms of enzyme-catalyzed reactions, with an emphasis on organic and organometallic cofactors in biology and mechanisms of group transfer reactions, redox reactions, rearrangements, decarboxylations, carboxylations, and methylation.

CHEM 536 / MACROMOL 536. Laboratory in Macromolecular Chemistry
CHEM 535 or PHYSICS 418 or permission of instructor. (3). (BS). May not be repeated for credit.

Experimental methods for the study of macromolecular materials in solution and in bulk state.

CHEM 538 / MACROMOL 538. Organic Chemistry of Macromolecules
CHEM 215/216, and CHEM 230 or 260. (3). (BS). May not be repeated for credit. W.

CHEM 540. Organic Principles
CHEM 312 and 461. (3). (BS). May not be repeated for credit.

CHEM 541. Advanced Organic Chemistry
CHEM 540. (3). (BS). May not be repeated for credit. W.

CHEM 542. Applications of Physical Methods to Organic Chemistry
CHEM 260, 241/242, and 312. (3). (BS). May not be repeated for credit.

Applications of infrared, ultraviolet and nuclear magnetic resonance spectroscopy, optical rotary dispersion, mass spectrometry and other physical methods to the study of the structure and reactions of organic compounds.

CHEM 543. Organic Mechanisms
CHEM 215/216. (3). (BS). May not be repeated for credit.

Students will learn to propose and write reasonable mechanisms for organic reactions, including complex multi-step processes. Knowledge of the details of the fundamental organic reaction processes will also be gained.

CHEM 548. New Frontiers at the Chemistry/Biology Interface
Permission of Instructor. (1). (BS). May be repeated for a maximum of 2 credits.

Students in this course will attend seminars that describe topics at the frontiers of Chemistry and Biology. Class discussion of each seminar will take place approximately one week prior to the date and be lead by a student participant.

CHEM 551 / BIOINF 551 / BIOLCHEM 551 / BIOMEDE 551 / PATH 551. Proteome Informatics
The course is fundamentally interdisciplinary. Undergraduate biochemistry and calculus, or permission of instructor. (3). (BS). May not be repeated for credit.

Introduction to proteomics, mass spectrometry, peptide identification and protein inference, statistical methods and computational algorithms, post-translational modifications, genome annotation and alternative splicing, quantitative proteomics and differential protein expression analysis, protein-protein interaction networks and protein complexes, data mining and analysis of large-scale data sets, clinical applications, related technologies such a metabolomics and protein arrays, data integration and systems biology.

CHEM 567 / AOSS 567. Chemical Dynamics
CHEM 461 or AOSS 479 or permission of instructor. (3). (BS). May not be repeated for credit.

CHEM 570. Molecular Physical Chemistry
(3). (BS). May not be repeated for credit.

Basic concepts in modern chemical physics including molecular symmetry, group theory, operators, and introduction to the electronic structure of atoms and molecules.

CHEM 571. Quantum Chemistry
CHEM 570; Graduate standing and permission of instructor. (3). (BS). May not be repeated for credit.

CHEM 575. Chemical Thermodynamics
CHEM 461. (3). (BS). May not be repeated for credit.

CHEM 576 / APPPHYS 576. Statistical Mechanics
Graduate standing and permission of instructor. (3). (BS). May not be repeated for credit.

CHEM 580. Molecular Spectra and Structure
CHEM 570 or permission of instructor. (3). (BS). May not be repeated for credit. W.

CHEM 597. Introduction to Graduate Research
Graduate standing. (3). May be repeated for a maximum of 6 credits. This course has a grading basis of "S" or "U".

All Chemistry PhD students are required to take a first-year graduate research course both Fall and Winter terms. This course consists of practical hands-on experience in a faculty's lab. Students will receive training in research methods and techniques necessary for the successful conduct of dissertation research as the new curriculum changes require.

CHEM 598. Integrated Graduate Education and Research Training Program (IGERT) Research Rotation
Graduate standing. (3). May be elected four times for credit. This course has a grading basis of "S" or "U".

Students will conduct research in a laboratory setting.

CHEM 599. Chemistry Biology Interface (CBI) Training Program Research Rotation
Graduate standing. (3). May not be repeated for credit.

CHEM 602 / BIOLCHEM 602 / BIOPHYS 602 / PHRMACOL 602. Protein Crystallography: Principles of Macromolecular Crystallography
Physical Chemistry. Graduate standing. (3). (BS). May not be repeated for credit.

Fundamental of the methods for determining 3-dimensional structures of large molecules by x-ray crystallography. Aimed at students who expect to use crystallography as a major tool for their research, and at those who want in-depth knowledge of the methods in order to analyze structure data.

CHEM 616. Advanced Inorganic Chemistry
Basic knowledge of group therapy. Graduate standing. (3). May not be repeated for credit.

The application of theoretical principles to understand the theoretical background of key optical and vibrational spectroscopic techniques. These include electronic absorption, electron paramagnetic resonance (EPR), magnetic circular dichroism (MCD), Mossbauer, and resonance Raman Spectroscopy. In addition, a brief introduction to magnetism and magnet susceptibility, and modern quantum-chemical calculations (in particular, density functional theory) is provided.

CHEM 646. Separation Processes
CHEM 545 and graduate standing. (3). May not be repeated for credit.

CHEM 647. Mass Spectrometry
Undergraduate instrumental analysis. (3). May not be repeated for credit.

This course is focused on gaining a deep understanding of the physical principles of this technique, including generation and measurement of high vacuum, sample introduction systems, ionization methods, ion optics, mass analysis, ion detection, electronics, and data processing. Methods for tandem mass spectrometry (MS/MS) experiments are also discussed in detail, including collision induced dissociation, surface induced dissociation, photo dissociation, and techniques involving radical ion chemistry, e.g. electron capture and transfer dissociation, as well a implementation of MS/MS on various mass analyzers.

CHEM 648. Analysis Spectroscopic and Imaging
CHEM 447 and Graduate standing. Permission of instructor. (3). May not be repeated for credit.

CHEM 649. Electrochemistry
CHEM 447 and Graduate standing. (2 - 3). May not be repeated for credit.

The course will introduce and discuss the fundamental processes necessary for understanding electrochemical systems. The common methods and interpretation of experimental data will be presented. A description of experimental design and instrumentation will be given. As time permits, current and special topics in electrochemical research will be discussed.

CHEM 670 / BIOPHYS 670. Principles of Magnetic Resonance
CHEM 570 or permission of instructor and graduate standing. (2). May not be repeated for credit.

Classical and quantum mechanical treatments of magnetic resonance phenomena. Included will be discussion of spin systems, rotating fields, electron-nucleus interactions, and relaxation phenomena. Experimental and theoretical aspects of nuclear magnetic resonance, electron spin resonance, 2-D NMR and the product operator formalism; chemical shifts, spin-spin coupling, hyperfine interactions, spin-lattice relaxation, and other topics.

CHEM 673 / BIOLCHEM 673. Kinetics and Mechanism
BIOLCHEM 550, CHEMBIO 501, or equivalent, undergrad calculus. Physical Chemistry is recommended. (2). (BS). May not be repeated for credit.

This course will cover the investigation of enzyme mechanisms with an emphasis on ligand binding to macromolecules, transient kinetics, steady-state kinetics, and inhibition. The kinetic and thermodynamic concepts that govern the action of enzymes will be explored.

CHEM 711. Special Topics in Inorganic Chemistry
(3). May not be repeated for credit.

CHEM 744. Special Topics in Organic Chemistry
CHEM 541. Graduate standing. (2). May not be repeated for credit.

CHEM 750. Special Topics in the Chemical Sciences
Graduate standing or persmission of instructor. (2 - 3). May not be repeated for credit.

This course covers upper-level graduate areas of contemporary interest. Different sections of the class will focus on different areas of the chemical sciences (e.g., analytical, physical, organic, etc.), depending on the interest and demand for specific content areas.

CHEM 799. Selected Topics in Chemistry
Graduate standing and permission of instructor. (1 - 3). May not be repeated for credit.

CHEM 800. Seminar in Chemical Biology
Graduate standing. (2). May be repeated for a maximum of 12 credits. This course has a grading basis of "S" or "U".

Guest speakers lecturing on the topics of Chemical Biology.

CHEM 801. Seminar in Analytical Chemistry
Graduate standing. (2). May not be repeated for credit.

CHEM 802. Seminar in Inorganic Chemistry
Graduate standing. (2). May not be repeated for credit.

CHEM 803. Seminar in Organic Chemistry
Graduate standing. (2). May not be repeated for credit.

CHEM 804. Seminar in Physical Chemistry
Graduate standing. (2). May not be repeated for credit.

CHEM 805. Materials Seminar
Graduate standing. (2). May not be repeated for credit.

CHEM 806. Organic Departmental Seminar
Graduate standing. (1). May not be repeated for credit. This course has a grading basis of "S" or "U".

Guest speakers lecturing on the topic of organic chemistry.

CHEM 807. Analytical Departmental Seminar
Graduate standing. (1). May not be repeated for credit. This course has a grading basis of "S" or "U".

Guest speakers lecturing on the topic of analytica chemistry.

CHEM 808. Chem Bio Departmental Seminar
Graduate standing. (1). May not be repeated for credit. This course has a grading basis of "S" or "U".

Guest speakers lecturing on the topic of chemical biology.

CHEM 809. Inorganic Departmental Seminar
(1). May be repeated for a maximum of 2 credits. This course has a grading basis of "S" or "U".

Guest speakers lecturing on the topic of inorganic chemistry.

CHEM 810. Physical Departmental Seminar
Graduate standing. (1). May be repeated for a maximum of 2 credits. This course has a grading basis of "S" or "U".

Guest speakers lecturing on the topic of physical chemistry.

CHEM 811. Materials Departmental Seminar
Graduate standing. (1). May be repeated for a maximum of 2 credits. This course has a grading basis of "S" or "U".

Guest speakers lecturing on the topic of materials chemistry.

CHEM 895. Research in Chemistry
Consent of instructor required. Approval of Graduate Committee. Graduate standing and permission of instructor. (1 - 8; 1 - 4 in the half-term). (INDEPENDENT). May be elected three times for credit.

CHEM 990. Dissertation/Precandidate
Election for dissertation work by doctoral student not yet admitted as a Candidate. Graduate standing. (1 - 8; 1 - 4 in the half-term). (INDEPENDENT). May be repeated for credit. This course has a grading basis of "S" or "U".

CHEM 993. Graduate Student Instructor Training Program
Must have GSI award. Graduate standing. (1). May not be repeated for credit. This course has a grading basis of "S" or "U".

CHEM 995. Dissertation/Candidate
Graduate School authorization for admission as a doctoral Candidate. (Prerequisites enforced at registration.) (8; 4 in the half-term). (INDEPENDENT). May be repeated for credit. This course has a grading basis of "S" or "U".

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