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Courses in LSA Molecular, Cellular, and Developmental Biology
Molecular, Cellular, and Developmental Biology (MCDB)
MCDB 400. Advanced Research
MCDB 300. (Prerequisites enforced at registration.) 12 credits of biology, 3.0 average in science, and permission of faculty member in biology. (1 - 3). (BS). (INDEPENDENT). May be repeated for a maximum of 9 credits. Continuing Course. Y grade can be reported at end of the first-term to indicate work in progress. At the end of the second term of MCDB 400, the final grade is posted for both term's elections. Three credits of independent research must be completed in one term to satisfy a Biology laboratory requirement. A maximum of three credits of any independent study course may count toward the Biology concentration programs.

MCDB 401. Advanced Topics in Biology
CMB senior concentrators or Graduate standing. Prerequisites will be set by the instructor as appropriate for each section. (3). (BS). May be repeated for a maximum of 6 credits.

MCDB 402. Molecular Biology of Pain and Sensation
BIOLOGY 222 or BIOLOGY 225 or MCDB 422. (Prerequisites enforced at registration.) BIOLOGY 305; MCDB 310, BIOLCHEM 415 or CHEM 351; and MCDB 423. (3). (BS). May not be repeated for credit. Rackham credit requires additional work.

The course examines how pain and sensory stimuli such as odors, touch, and temperature are transformed into a cellular response. It is divided between lectures and group discussions, with most assigned readings chosen from primary research articles.

MCDB 403. Molecular and Cell Biology of the Synapse
One of: MCDB 310, MCDB 311, BIOLCHEM 415, or CHEM 351. (Prerequisites enforced at registration.) BIOLOGY 305 and MCDB 422. (3). (BS). May not be repeated for credit. Rackham credit requires additional work.

The overall aim of this course is to introduce students to the most recent advances in a rapidly growing topic of neuroscience: synaptic plasticity or the change in nerve cell connection efficacy over time. The course is divided into lectures (the first half of the semester and related papers discussions (the second half of the semester).

MCDB 404 / EEB 404. Genetics, Development, and Evolution
BIOLOGY 305. (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit.

This course introduces students to the field of evolution and development, with an emphasis on genetics as a unifying force. After reviewing fundamental principles in development and evolutionary biology, papers from the primary literature investigating the molecular mechanisms responsible for evolutionary change will be discussed.

MCDB 405. Molecular Basis of Development
BIOLOGY 305; or graduate standing. (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit.

MCDB 408. Genomic Biology
BIOLOGY 305; and MCDB 310, BIOLCHEM 415, or CHEM 351. (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit. Rackham credit requires additional work.

This course introduces students to the methods and research topics encompassed within the discipline of genomics. Students investigate the methods used to sequence genomes as well as methods currently being developed to analyze gene and protein function on a large scale across a diverse spectrum of eukaryotes.

MCDB 411. Protein Structure and Function
MCDB 310, BIOLCHEM 415, or CHEM 351. Or Graduate standing. (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit. F.

This course is a practical hands-on approach to extract information about a protein sequence by using protein sequence analysis tools available on the web. Students also identify 3D protein structural motifs, discuss how they are related to the protein's functions and discuss how proteins fold.

MCDB 415. Microbial Genetics
BIOLOGY 305; and MCDB 310, BIOLCHEM 415, or CHEM 351. Or Graduate Standing. (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit.

This course is a lecture-based course covering the principal aspects of microbial genetics, with special emphasis on model organisms. We will review the current state of recombinant DNA research and discuss the application of these techniques to solving problems in basic and applied research fields. Each day class time will be devoted to group problem solving. Students will be encouraged and expected to participate in group discussions and problem solving.

MCDB 417. Chromosome Structure and Function
BIOLOGY 305. (3). (BS). May not be repeated for credit. Rackham credit requires additional work.

This course focuses on understanding how the structure of a chromosome affects in mitotic and interphase functions. Topics include assembly of chromatin and chromosomes, euchromatin and heterochromatin, epigenetics, and gene regulation. A combination of lecture, literature review, and in class discussion is used to explore genetic, biochemical, and cytological methods for defining our current knowledge and chromosomes.

MCDB 418. Endocrinology
A course in animal of human physiology (BIOLOGY 225 is preferred), a course in biochemistry (MCDB 310 is preferred) and a course in genetics (BIOLOGY 305 is preferred). (3). (BS). May not be repeated for credit. F.

This course is a comparative study of animal endocrine functions with emphasis on the cellular origin and chemical nature of hormones, the cellular and molecular mechanisms of hormone action, general endocrine control mechanisms, the evolution of hormones and hormonal control and their physiological actions in animals. The course will concentrate on the endocrine systems of vertebrates; there will be limited treatment of human endocrinology.

MCDB 419. Endocrinology Laboratory
Prior or concurrent enrollment in BIOLOGY 225 or 310 or 311, or MCDB 418 or 426. (3). (BS). May not be repeated for credit. F. Satisfies a Biology laboratory requirement.

The laboratory course provides hands-on experience with methods used in endocrinological investigations. The students will learn techniques ranging from the organismal to the molecular level. The course emphasizes hypothesis testing, modern techniques, and data analysis.

MCDB 422. Brain Development, Plasticity, and Circuits
MCDB 310 or 311, or BIOLCHEM 415, or CHEM 351; or graduate standing. (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit. F.

The course presents mechanisms underlying the development, plasticity and regeneration of the nervous system and function of neural circuits. There is an emphasis on experiments using molecular and cellular approaches in genetically amenable animals. Topics covered include neurogenesis, axon guidance, synapse formation, regeneration and molecular analysis of circuit function.

MCDB 423. Introduction to Research in Cellular and Molecular Neurobiology
BIOLOGY 225 or BIOLOGY 222; or concurrent enrollment in MCDB 422. (3). (BS). May not be repeated for credit. F and W. Satisfies a Biology laboratory requirement.

This course provides an introduction to state-of-the-art research approaches in cellular and molecular neurobiology. The course is divided into three modules: electrophysiological methods, anatomical methods, and molecular biological methods.

MCDB 426. Molecular Endocrinology
BIOLOGY 225; and one of: MCDB 310 or 311, or BIOLCHEM 415, or CHEM 351; or Graduate standing. (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit.

Introduces students to the latest advances in our understanding of how hormones work at the molecular and cellular level in vertebrate systems, including humans. Topics include gene structure, expression, regulation, and cellular actions of various hormones.

MCDB 427. Molecular Biology
BIOLOGY 305, and one of MCDB 310 or BIOLCHEM 415 or CHEM 351; OR Graduate standing. (Prerequisites enforced at registration.) (4). (BS). May not be repeated for credit. F.

Lectures and discussions are concerned with the following topics: the physical methods used in molecular biology; structure and coding capacity of DNA chromosomes; DNA replication; transcription, protein synthesis; prokaryotic and eukaryotic regulation; molecular aspects of development; transposable elements and genetic engineering.

MCDB 428. Cell Biology
MCDB 310, BIOLCHEM 415, or CHEM 351. Or Graduate standing. (Prerequisites enforced at registration.) (4). (BS). May not be repeated for credit. Students with credit for MCDB 320 must obtain permission of instructor. W.

The following topics are included: methods for handling relevant organisms; general properties of membranes; secretion, endocytosis, and related processes; functions and biogenesis of cell walls, of mitochondria, or chloroplasts; cellular organization of energy metabolism in prokaryotes; cytoskeleton and cell motility; structural organization and functional consequences of nuclei and nucleoids; cell cycle and its regulation; cellular aspects of differentiation and development; functions of specialized cell types.

MCDB 429. Laboratory in Cell and Molecular Biology
MCDB 427 or 428, or concurrent enrollment in MCDB 428. (3). (BS). May not be repeated for credit. No credit granted to those who have completed or are enrolled in BIOLCHEM 416 or 516. This course can be used to satisfy requirements for the Cell and Molecular Biology Concentration and the Biology Concentration. W. Satisfies a Biology laboratory requirement.

MCDB 430. Molecular Biology of Plants
BIOLOGY 305; and MCDB 310, BIOLCHEM 415, or CHEM 351. Or Graduate standing. (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit. W.

Basic aspects of molecular genetic/biochemistry as they pertain to plants: genome and gene structure and expression; processes of protein synthesis and localization; and the interaction of these macromolecules within and between cells.

MCDB 433. Plant Metabolic Biochemistry
BIOLOGY 305 and (MCDB 310, BIOLCHEM 415, or CHEM 351). (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit.

The course examines the major biochemical pathways that occur in plants, with emphasis on the chemical reactions and pathways that are unique to plants.

MCDB 435. Intracellular Trafficking
BIOLOGY 305; or Graduate Standing. (Prerequisites enforced at registration.) MCDB 428. (3). (BS). May not be repeated for credit.

Topics covered include molecular basis of secretion, vesicle transport, protein targeting, molecular motors and organelle biogenesis. Students are presented lectures introducing them to current issues, and then read the latest experimental papers anticipated having a large impact in the field. The course includes critical discussions of the experiments, interpretations, and conclusions of primary research papers.

MCDB 436. Introductory Immunology
MCDB 310, BIOLCHEM 415, or CHEM 351. Or Graduate standing. (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit. Only one of MICRBIOL 440 or IMMUNO 440 or MCDB 436 weill count toward a Microbiology major.

Detailed study of the organs, cells, and molecules that constitute the human immune system; cellular interactions involved in initiating and mediating an immune response; role of the immune system in organ transplants, cancer therapy, and immunodeficiency diseases; use of Polyclonal and Monoclonal Antibodies as precise probes in all fields of modern biological and biomedical research.

MCDB 437. Microbial Communication and Development
BIOLOGY 305; and one of: MCDB 310 or BIOLCHEM 415 or CHEM 351. (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit. Rackham credit requires additional work.

This course explores the ongoing research on different aspects of microbial communication and development including certain social phenomena like quorum sensing, biofilm development and swarming motility. Readings are from the primary literature.

MCDB 440. Cell Cycle Control and Cancer
Genetics (Bio 305) and Biochemistry (MCDB 310, CHEM 351, or BiolChem 415). (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit. Rackham credit requires additional work.

This course is an examination of current genetic and cell biology research on the topic of cell cycle control and cancer biology, designed for graduate and advanced undergraduates. This course involves introductory lectures, reading and analysis of current primary scientific literature and careful analysis of "pop-science" representations of cancer research.

MCDB 441. Cell Biology and Disease
Consent of instructor required. MCDB 428 and [MCDB 310 or MCDB 311 or BIOLCHEM 415 or CHEM 351]. (3). May not be repeated for credit. Rackham credit requires additional work.

This course will extend the basic knowledge of molecular cell biology into cellular disorders in human diseases. The course will be comprised of lectures, in-class discussions, paper readings, and presentations. It is appropriate for students interested in cell biology, biochemistry, molecular biology, pharmacology, and genetics.

MCDB 444. Bacterial Cell Biology
BIOLOGY 305; and MCDB 310, BIOLCHEM 415, or CHEM 351. Or Graduate standing. (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit. Rackham credit requires additional work.

This course explores a wide range of cell biological topics in bacteria, ranging from the synthesis of external structures such as flagella and pili to the role of cytoskeletal proteins in the spatial localization of proteins. Readings are from the primary literature.

MCDB 450. Genetics and Molecular Biology of Complex Behavior
BIOLOGY 222 or 225; BIOLOGY 305; and, one of: MCDB 310, BIOLCHEM 415, or CHEM 351. (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit. Rackham credit requires additional work.

This course explores recent advances in the genetics and molecular biology of brain function and complex behavior. It emphasizes advances due to the application of genetic strategies that uncovered molecules important for complex behavior and brain function in organisms amenable to genetic analysis such a Drosophila, C. elegans, zebrafish, and mice.

MCDB 454. Cytoskeletal Dynamics
BIOLOGY 305; and one of: MCDB 310 or BIOLCHEM 415 or CHEM 351. (Prerequisites enforced at registration.) MCDB 427 and/or MCDB 428. (3). (BS). May not be repeated for credit. Rackham credit requires additional work.

Cytoskeletal dynamics drives key cellular processes including cell shape change, organelle movement, cell migration, and cell division. This advanced biology course uses primary literature as a tool to discuss key concepts and techniques related to the cytoskeleton and further helps students gain an appreciation of how scientific knowledge is generated.

MCDB 455. Cell Biology of Neurodegeneration
BIOLOGY 222 or 225 or 305; and MCDB 310 or BIOLCHEM 415 or CHEM 351. (Prerequisites enforced at registration.) MCDB 422 or 428. (3). (BS). May not be repeated for credit. Rackham credit requires additional work.

This course covers current research into the cellular mechanisms that underlie neurodegenerative disorders, focusing on Alzheimer's Disease, Parkinson's Disease, ALS, and Multiple Sclerosis. Class will consist predominantly of discussion of scientific papers, and evaluation will be based on daily quizzes, participation, and a scientific research proposal.

MCDB 456. Genes, Circuits, and Behavior
BIOLOGY 222 or 225 or MCDB 422; and BIOLOGY 305. (Prerequisites enforced at registration.) MCDB 310 or BIOLCHEM 415 or CHEM 351. (3). (BS). May not be repeated for credit. Rackham credit requires additional work.

This course explores model systems neuroscience through guided reading of seminal works of experimental neuroscience and current primary scientific literature. Strong focus is placed on newly emerging systems approaches to the neuronal control of behavior that integrate gene-function, neuroanatomy, live-imaging, and quantitative behavioral analysis.

MCDB 462. Epigenetics
BIOLOGY 305; and one of MCDB 310 or BIOLCHEM 415 or CHEM 351. (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit.

This course is an introduction to epigenetics, the exciting field of research about heritable changes in gene function that cannot be explained by changes in DNA sequence. Topics include chromatin structure, establishment and maintenance of chromatic modifications, non-coding RNA biology, and implications of epigenetic mechanisms for human health.

MCDB 471. Advanced Methods in Biochemistry
MCDB 310, CHEM 351, or BIOLCHEM 415, or grad standing. (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit. Rackham credit requires additional work.

The course introduces upper-level undergraduates and graduate students to a wide range of quantitative methods used in modern biochemistry.

MCDB 489. Microbial Genes and Genomes
BIOLOGY 305; and one of: MCDB 310 or 311, or BIOLCHEM 415, or CHEM 351; or graduate standing. (Prerequisites enforced at registration.) (3). (BS). May not be repeated for credit.

This course covers a broad range of pathways used by bacteria to replicate and maintain their genetic material. The course covers genetic, cell biological, biochemical, and modern genomic techniques. The course material is from the primary literature.

MCDB 494 / EEB 494. Teaching College Science
Consent of department required. Science concentrators having completed a range of courses, such as BIOLOGY 171,172 and 173; BIOLOGY 225, 281, 305 or EEB 390; CHEM 130, 210 or 211; PHYSICS 140 or 160; or EARTH 119. (2). (BS). May not be repeated for credit.

This course helps students build a foundation of knowledge about effective science teaching. It is both scholarly and practical in nature. Students construct an understanding of fundamental principles and sound pedagogy that they apply to their own teaching.

MCDB 608 / BIOPHYS 608 / PHYSICS 608. Biophysical Principles of Microscopy
PHYSICS,Knowledge of complex exponential notation, and graduate standing. Physics 405 or permission of instructor. (3). May not be repeated for credit.

MCDB 610 / NEUROSCI 601. Principles Neuroscience I
Enrollment in a Ph.D. program. Graduate students in Master's degree programs may register only with the permission of the instructor. (4). (BS). May not be repeated for credit. F.

MCDB 611 / NEUROSCI 611. Excitable Membranes
Enrollment in a Ph.D. program. Graduate students in Master's degree programs may register only with the permission of the instructor. (1). (BS). May not be repeated for credit.

MCDB 613 / NEUROSCI 613. Central Nervous System Physiology and Development
Enrollment in a Ph.D. program. Graduate students in Master's degree programs may register only with the permission of the instructor. (1). (BS). May not be repeated for credit.

MCDB 614. Experimental Models in Molecular, Cellular and Developmental Biology
REQUIRED - ENROLLMENT IN A LIFE SCIENCE PH.D PROGRAM. RECOMMENDED - INTRODUCTORY COURSES IN GENETICS AND BIOCHEMISTRY. (3). May not be repeated for credit.

This course introduces beginning Ph.D students to model organisms widely used in molecular, cellular and developmental biology research and to several powerful experimental approaches that can be used to study these organisms. The emphasis is on understanding the types of experiments for which each organism is particularly well suited.

MCDB 615. Topics in Cellular and Molecular Biology
Consent of instructor required. MCDB 427 and 428; Graduate standing and permission of instructor. (3). May be elected twice for credit.

MCDB 623 / NEUROSCI 623. Cellular and Molecular Neuroscience Lab
Concurrent enrollment in Neuroscience 601 or previous completion of Neuroscience 601. (3). (BS). May not be repeated for credit.

The course introduces graduate pursuing doctoral training in Neuroscience to state of the art approaches in electro-physiology, cellular anatomy and molecular biology. At the completion of this course the student should be prepared to undertake the independent research in most areas of molecular neurobiology.

MCDB 632 / HUMGEN 632 / MICRBIOL 632. Experimental Genetics Systems
Graduate standing, and current or past Genetics Training Program student. (1). (BS). May be elected three times for credit. F. This course has a grading basis of "S" or "U".

Two faculty members per session describe their application of genetics principles to analysis of specific biological questions. This new course is designed to provide Genetics Training Program students with systematic exposure to the range of genetics approaches in use within the Program, and to increase interaction between students and faculty in the program.

MCDB 680 / CDB 680 / CMBIOL 680 / HUMGEN 680 / NEUROSCI 680 / PATH 680 / PHYSIOL 680. Organogenesis of Complex Tissues
Cell Biology, Developmental Biology or permission of instructor. (3). (BS). May be elected six times for credit.

This course will cover multiple aspects of organogenesis, including: morphological and molecular events underlying organ formation; quantitative aspects of gradient formation, tissue modeling and cell behavior; in vitro and in vivo experimental systems; parallel pathways for organ formation in various model organisms; adult organ structure and pathology; organ regeneration/repair; stem cell systems; cell and tissue engineering; and carcinogenesis. Three modules make up the course: a) stem cells and cell signaling; b) organogenesis of the gut (the organ system changes each year); c) an exercise in writing a scientific proposal. Course objectives are: a) to provide students with a current, in-depth, multidisciplinary view of the processes of organogenesis; b) to highlight target areas of future research; c) to read and discuss significant papers in the field; and d) to practice the design and preparation of a research grant by writing a "miniproposal".

MCDB 682 / CDB 681 / CMBIOL 681 / HUMGEN 681 / NEUROSCI 681 / PATH 681 / PHYSIOL 681. Organogenesis of Complex Tissues
Cell Biology, Developmental Biology or permission of instructor. (2). (BS). May be elected six times for credit.

This course will cover multiple aspects of organogenesis, including: morphological and molecular events underlying organ formation; in vitro and in vivo experimental systems; parallel pathways for organ formation in various model organisms; adult organ structure and pathology; organ regeneration/repair; stem cell systems: cell and tissue engineering; and carcinogenesis. Two modules make up the course a) organogenesis of the gut (the organ system changes each year); b) an exercise in writing a scientific proposal. Course objectives are: a) to provide students with a current, in-depth, multidisciplinary view of the processes of organogenesis; b) to highlight target areas of future research; c) to read and discuss significant papers in the field; and d) to practice the design and preparation of a research grant by writing a "miniproposal".

MCDB 683 / CDB 682 / CMBIOL 682 / HUMGEN 682 / NEUROSCI 682 / PATH 682 / PHYSIOL 682. Organogenesis of a Complex Tissue
Graduate Cell biology recommended, but not required. Graduate standing. (2). (BS). May not be repeated for credit.

This course will cover multiple aspects of organogenesis, including: morphological and molecular events underlying organ formation; in vitro and in vivo experimental systems; parallel pathways for organ formation in various model organisms; adult organ structure and pathology; organ regeneration/repair; stem cell systems: cell and tissue engineering; and carcinogenesis. Two modules make up the course a) organogenesis of the gut (the organ system changes each year); b) an exercise in writing a scientific proposal. Course objectives are: a) to provide students with a current, in-depth, multidisciplinary view of the processes of organogenesis; b) to highlight target areas of future research; c) to read and discuss significant papers in the field; and d) to practice the design and preparation of a research grant by writing a "miniproposal".

MCDB 700. Advanced Studies
Consent of instructor required. BIOLOGY,Permission of instructor. (1 - 8). (INDEPENDENT). May not be repeated for credit.

MCDB 800. Biology Seminars
Consent of instructor required. Graduate standing and permission of instructor. (1). May not be repeated for credit.

MCDB 801. Supervised Teaching
Consent of instructor required. Graduate standing and permission of instructor. Appointment as Teaching Assistant in Biology. (1 - 2). (EXPERIENTIAL). May not be repeated for credit.

MCDB 990. Dissertation/Precandidate
Election for dissertation work by doctoral student not yet admitted as a Candidate. Graduate standing. (1 - 8; 1 - 4 in the half-term). (INDEPENDENT). May be repeated for credit. This course has a grading basis of "S" or "U".

MCDB 995. Dissertation/Candidate
Graduate School authorization for admission as a doctoral Candidate. (Prerequisites enforced at registration.) (8; 4 in the half-term). (INDEPENDENT). May be repeated for credit. This course has a grading basis of "S" or "U".

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