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Courses in MED Neuroscience Laboratory
Neuroscience (NEUROSCI)
NEUROSCI 520 / PSYCH 533. Sleep: Neurobiology, Medicine, and Society
Senior and above. (Prerequisites enforced at registration.) BIOLOGY 222, MCDB 422, or PSYCH 230; and permission of instructor. (3). (BS). May not be repeated for credit.

The objective of this course is to give students the most up-to-date information on the biological, personal, and societal relevance of sleep. Personal relevance is emphasized by the fact that the single best predictor of daytime performance is the quality of the previous night's sleep. The brain actively generates sleep, and the first third of the course will overview the neurobiological basis of sleep cycle control. Sleep will be used as a vehicle for teaching basic neuroanatomical and neuropharmacological principles. This information will provide a cellular-level understanding of how sleep deprivation, jet lag, and substances such as alcohol, caffeine, and nicotine alter sleep and wakefulness. It is now clear that sleep significantly alters physiology. The second third of the class will cover sleep-dependent changes in physiology and sleep disorders medicine. Particular emphasis will be place on disorders of excessive sleepiness, insomnia, and sleep-dependent changes in autonomic control. Chronic sleep deprivation impairs immune function and promotes obesity. Deaths due to all causes are most frequent between 4 and 6 a.m., and the second portion of the class will highlight the relevance of sleep for preventive medicine. The societal relevance of the sleep will be considered in the final portion of the class. In an increasingly complex and technologically oriented society, operator-error by one individual can have a disastrous negative impact on the public health and safety. Fatigue-related performance errors contributed to the Three Mile Island and Chernobyl nuclear power plant failures and to the Exxon Valdez Alaskan oil spill. The personal relevance of fatigue-related performance errors will be considered by reviewing the recent data showing that in the U.S. more people die from medical mistakes each year than from highway accidents, breast cancer, or AIDS. Fulfillment of course objectives will be quantified by pre- versus post-class informational self-evaluation. In-class arousal levels will be facilitated by seminar participation.

NEUROSCI 601 / MCDB 610. Principles Neuroscience I
Enrollment in a Ph.D. program. Graduate students in Master's degree programs may register only with the permission of the instructor. (3). (BS). May not be repeated for credit. F.

NEUROSCI 611 / MCDB 611. Neurochemistry/Neuropharmacology
Enrollment in a Ph.D. program. Graduate students in Master's degree programs may register only with the permission of the instructor. (1). (BS). May not be repeated for credit.

This course covers the neurochemistry and neuropharmacology of the major neurotransmitter system.

NEUROSCI 613 / MCDB 613. Circuits and Computational Neuroscience
Enrollment in a Ph.D. program. Graduate students in Master's degree programs may register only with the permission of the instructor. (1). (BS). May not be repeated for credit.

This course addresses neuronal activity within specific circuits and the application of computational methods to understand the analyze neuronal and circuit function (MatLab).

NEUROSCI 623 / MCDB 623. Cellular and Molecular Neuroscience Lab
Concurrent enrollment in Neuroscience 601 or previous completion of Neuroscience 601. (3). (BS). May not be repeated for credit.

The course introduces graduate pursuing doctoral training in Neuroscience to state of the art approaches in electro-physiology, cellular anatomy and molecular biology. At the completion of this course the student should be prepared to undertake the independent research in most areas of molecular neurobiology.

NEUROSCI 682 / CDB 682 / CMBIOL 682 / HUMGEN 682 / MCDB 683 / PATH 682 / PHYSIOL 682. Organogenesis of a Complex Tissue
Graduate Cell biology recommended, but not required. Graduate standing. (2). (BS). May not be repeated for credit.

This course will cover multiple aspects of organogenesis, including: morphological and molecular events underlying organ formation; in vitro and in vivo experimental systems; parallel pathways for organ formation in various model organisms; adult organ structure and pathology; organ regeneration/repair; stem cell systems: cell and tissue engineering; and carcinogenesis. Two modules make up the course a) organogenesis of the gut (the organ system changes each year); b) an exercise in writing a scientific proposal. Course objectives are: a) to provide students with a current, in-depth, multidisciplinary view of the processes of organogenesis; b) to highlight target areas of future research; c) to read and discuss significant papers in the field; and d) to practice the design and preparation of a research grant by writing a "miniproposal".

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